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KMID : 0352120200350010011
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Journal of Kyung Hee University
2020 Volume.35 No. 1 p.11 ~ p.16
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Comparison of Fentanyl and Sufentanil Intravenous Patient-controlled Analgesia after Laparoscopic Surgery: A Retrospective Study
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Chung Kum-Hee
Lee Seung-Hoon
Kwak Ha-Yeon
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Abstract
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Purpose: Postoperative pain affects patient recovery and can cause negative consequences. Fentanyl is widely used for postoperative pain management, but its side effects include nausea, vomiting, bradycardia, hypotension and itching. Sufentanil, which is 5 to 10 times more potent than fentanyl, has a fast onset and short duration of action. We compared the analgesic and side effects of fentanyl and sufentanil used in intravenous patient-controlled analgesia (IV PCA) after surgery in gynecological patients undergoing laparoscopic surgery.
Methods: A retrospective study was conducted on patients who underwent laparoscopic hysterectomy or laparoscopic myomectomy between January-April 2012 and January-April 2016. Depending on the opioid used for IV PCA, 21 patients with fentanyl 1000 mcg, 20 patients with sufentanil 150 mcg, and 26 patients with sufentanil 200 mcg were included in this study. The pain scores and side effects in each group were evaluated immediately after the surgery and at 1, 24, and 48 hours after surgery.
Results: There was no significant difference in pain scores among the three groups and there was no significant difference in the incidence of bradycardia, hypotension and pruritus. Incidences of nausea and vomiting were significantly lower in patients with sufentanil 150 mcg.
Conclusion: In patients undergoing laparoscopic surgery, using sufentanil for IV PCA may reduce side effects while achieving analgesic effects similar to those achieved with fentanyl.
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KEYWORD
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Fentanyl, Sufentanil, Analgesia, Patient-Controlled
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